Direct-to-Biology (D2B)
Local chemistry, faster discovery
Direct-to-biology (D2B) can significantly accelerate early drug discovery — but only when the chemistry is reliable, the reaction conditions are fit for purpose, and the analytical control is rigorous. At its Frankfurt laboratory (Industriepark Höchst), Enamine Germany brings these together, giving European research teams direct access to experienced medicinal chemists and custom synthesis performed within the EU.
- Synthesis
- Frankfurt, EU
- Enamine Collection
- 573,000+ blocks
- Modalities
- Covalents · Glues · PROTACs
- Biology
- In-house + CRO network
Custom Libraries Built Around Your Target
Full access to Enamine's building-block collection — one of the largest in the world — lets us systematically explore chemical diversity, including covalent warheads, linkers, molecular-glue scaffolds and specialized building blocks.
Reliable Miniaturized Synthesis
Our chemists develop and optimize conditions for parallel, high-throughput synthesis, maximizing conversion and reproducibility so that crude mixtures are fit for direct screening.
A Natural Fit for Degraders and Molecular Glues
Molecular-glue discovery is largely empirical and screening-driven — exactly where D2B excels. High-throughput make-and-test lets us survey large numbers of analogs quickly to find and refine glue activity, alongside PROTACs and other targeted-degradation modalities.
Analytical Confidence
Reaction-mixture and compound characterization flags incomplete conversions, impurities and likely sources of assay interference before they reach biology.
Faster Design–Make–Test Cycles
Synthesis in the EU means close communication, same-day decisions in your time zone, rapid library adjustments and quick follow-up on confirmed hits — without transatlantic synthesis and shipping.
Integrated Biological Support
Our group's biology teams in Poland and Ukraine support assay planning, screening and data interpretation; for specialized assays we can also draw on a trusted CRO network to find the right fit for each project.
From Your Research Question to a Practical D2B Workflow
Whether you are working on covalent inhibitors, molecular glues, PROTACs, macrocycles or other challenging series, Enamine Germany offers more than compound synthesis. We help translate a biological objective into a feasible chemical library, select appropriate synthetic conditions, and establish the analytical controls that make screening data meaningful. Bring a target, an assay or a library concept, and we can assess synthetic feasibility, identify suitable building blocks and outline a tailored D2B strategy.