MedChem Support
Accelerate your drug discovery with us
The success of a drug discovery project depends significantly on the ability to identify directions to optimize validated hit structures and effectively perform synthetic work toward various target molecules. Having access to the whole Enamine collection and technologies, as well as to a team of experienced chemists, makes Enamine Germany a unique partner that provides versatile services at different stages of your projects.
- Analogs From
- Stock + REAL
- Design
- MedChem + CADD
- Synthesis
- Parallel
- Coverage
- Hit → Lead
Hit-Validation and Analog Synthesis
In order to confirm the activity of primary hits, it is often necessary to quickly resynthesize or repurify compounds and generate close analogs for further testing, to be sure that the hit can be optimized and selected for follow-up. Parallel synthesis of compound libraries, as well as preparation of close analogs from the Enamine REAL Database, is the most common approach for early-stage research.
Hit-to-Lead Optimization (H2L)
Once promising hits are selected, optimization to lead structures is the next important stage. It is often crucial to apply various MedChem principles effectively, as well as Computer-Aided Drug Design (CADD), in lead generation. At the same time, synthetic feasibility of the generated compounds is a key factor in ensuring a quick H2L campaign.
Bioisostere Replacement and Scaffold Hopping
Widely used approaches for both hit and lead optimization, improving the pharmacodynamic and pharmacokinetic properties of compounds. It is important to have access to diverse, stock-available building blocks and scaffolds to quickly synthesize the designed compounds.
Structure–Activity Relationship (SAR) Investigation
An important process to identify specific features of the molecule and determine their impact on the activity. For effective SAR, it is critical to apply stock-available building blocks to ensure rapid synthesis of versatile analogs.