Hit Follow-up Support
From a confirmed hit to a lead series, without changing supplier
The success of a hit finding campaign depends heavily on the quality of the screening library and on the hit confirmation process. We offer seamless support in following up the hits identified after screening of our compound libraries — confirming they are real, expanding around them, and taking the series into lead optimization.
- Screening Collection
- 4.8M+
- Resynthesis
- ~3 weeks
- Analog Space
- Collection + REAL
- Hit to Lead
- ADME + PK
Hit Confirmation
Resynthesis follows in-house protocols and typically takes about three weeks.
- Dry samples resupplied from the same batch
- QC check
- HPLC repurification
- Chiral resolution
- Impurities identification
Hit Expansion
- Analogs in the screening collection, the REAL Database and REAL Space
- Follow-up library design and enumeration of new molecules
- In silico screening: pharmacophore modeling, docking calculations and MD simulations
Hit to Lead
- FTE-based chemistry support
- Broad ADME panel
- PK studies
Starting a Hit Follow-up
Send your hit structures as SMILES or an SD file. We search the Enamine collections around them and come back with a same-week proposal.
Compound Management for Library Customers
Buying a screening library also opens Enamine's compound management: storage in a dedicated low-temperature facility, and plate copies delivered for screening or hit confirmation on your order.