Custom Synthesis
Molecules that fulfil a specific need — not only those that are readily accessible
Deep knowledge of synthetic organic chemistry, proficiency in modern methodologies and the ability to apply our skills and experience allow our team to quickly assess existing synthetic routes, identify challenges and potential points to improve, and propose novel alternatives for evaluation. By harnessing the expertise of our team of skilled chemists and scientists, we tackle challenges at every stage of the discovery process — pushing the boundaries of what is possible and striving to create molecules that fulfil specific needs or goals, rather than just those that are readily accessible.
- Bench Chemists
- Up to 35
- Scale
- mg to 0.5–1 kg
- Analytics
- LCMS · NMR
- Models
- FFS · FTE
Chemistry Skills
- Parallel synthesis
- Photochemistry
- Peptide synthesis
- Electrochemistry
- Scale up to 0.5–1 kg
- Macrocycles
- Spiro, bridged and fused bicycles
- Covalent binders
- Heterobifunctional compounds
- Organofluorine chemistry
Our Capabilities
- New site in Germany, in Höchst Industrial Park, Frankfurt am Main, with capacity for up to 35 bench chemists
- Modern, well-equipped lab space with all the infrastructure required for organic synthesis
- Direct access to a unique collection of Enamine building blocks and intermediates
- Analytical equipment: LCMS and NMR
- Normal- and reverse-phase column chromatography for milligram- to gram-scale purification
- Compound storage and management, with well-validated logistics
- Research-grade synthesis throughout — the Frankfurt site is not a GMP facility
Flexible Models of Collaboration
We offer flexible models of collaboration tailored to the specific needs, preferences and budget conditions of each client.
FFS — Fee-for-Service
Suits ordering compounds with defined structures. Based on the literature and on our own experience we provide a quote with timelines and costs; once the synthesis is performed, the customer is charged according to that quote.
FTE — Full-Time Equivalent
Makes sense for dynamic, flexible projects that require research and validation of synthetic routes. Dedicated chemists are fully engaged in the synthetic work, following the priorities you set and reporting regularly on progress. The customer is charged monthly at the FTE rate.
How the Engagement Works
- All intellectual property arising from the work belongs to you
- Written progress reports every two weeks
- Work starts under a signed Master Service Agreement and NDA
Features of Custom Synthesis with Enamine Germany
- High-quality project management
- Transparent communication with regular updates
- A diverse scope of projects
- Highly qualified chemists
- Availability of starting materials and building blocks
- IP protection