Fragment Libraries
Curated fragment collections for fragment-based drug discovery
Enamine's Fragment Collection contains 330,020 compounds for cherry-picking and specialized pre-plated libraries for fragment-based drug discovery. A separately tested subset contains 12,505 fragments with proven water-solubility data.
- Cherry-pick Fragments
- 330,020
- Water-solubility Subset
- 12,505
- Pre-plated Libraries
- 14
- Methods
- Multi-platform
Extensive Fragment Collection
The January 2026 Enamine Fragment Collection contains 330,020 compounds available for cherry-picking, supporting custom and pre-designed FBDD selections.
- 330,020 cherry-pick fragments
- Diverse chemotypes
- Custom library design
- Stock-backed hit follow-up
3D Fragment Libraries
Specialized collections featuring three-dimensional, sp³-rich fragments that explore underrepresented chemical space and offer improved binding specificity.
- Three-dimensional scaffolds
- sp³-rich compounds
- Unique chemical space coverage
- Enhanced binding specificity
Solubility & Screening Formats
A dedicated subset of 12,505 fragments has proven water-solubility data, and Enamine currently offers 14 pre-plated fragment libraries for different screening strategies.
- 12,505 water-solubility-tested fragments
- 14 pre-plated libraries
- X-ray and NMR-oriented sets
- SPR and thermal-shift options
Follow-up Chemistry Support
Beyond initial screening hits, we provide comprehensive support for fragment elaboration and lead optimization.
- Fragment elaboration support
- Analog synthesis capabilities
- SAR investigation services
- Lead optimization expertise